Baise-moi tells the story of Nadine and Manu who go on a violent spree against a society in which they feel marginalized. Nadine is a part-time sex worker, and Manu a slacker who does anything—including occasional porn film acting—to get by in her small town in southern France.
One day, Manu and her friend, a drug addict, are accosted in the park by three men, who take them to a garage and gang-rape them. While her friend struggles, screams, and fights against the rapists, Manu lies still with a detached look, which troubles the man raping her, who soon gives up. When her friend asks Manu how she could act so detached, she replies that she "can't prevent anyone from penetrating her pussy", so she didn't leave anything precious in there. Manu then returns to her brother's house, and does not tell him what has happened, but noticing bruises on her neck, he realizes. He gets out a gun and asks Manu who was responsible, but when she refuses to tell him, he calls her a "slut" and implies that she actually enjoyed being raped. In response, picking up the discarded pistol, Manu shoots him in the head.
Meanwhile, Nadine returns home and has an argument with her roommate, whom she strangles and kills, before leaving with their rent money. Nadine suffers another emotional setback when she meets her best friend, a drug dealer, in another town, but he is shot and killed while out obtaining drugs with a prescription she forged for him.
Later that night, having missed the last train, Nadine meets Manu at the railway station. Manu says she has a car, if Nadine will drive for her. They soon realize that they share common feelings of anger, and embark on a violent and sexually charged road trip together.
In need of money, the girls hold up a shop and also kill a woman at a cash machine. In a stolen car, they are pulled over for a random check by police, whom they kill. Another woman, who was also being checked and saw the murders, flees with them. The women stay over at their new friend's house, whose brother provides the address and details of an architect with whom he has had trouble. The women trick their way into the architect's house and kill him. Finally, after this spree of murder and sexual activity, the two women enter a swingers' club. One of the patrons makes a racist comment to Manu. The women kill most of the patrons there, and use a gun to anally penetrate the racist man, finally shooting him. The pair discuss what they have done, and agree that it has all been pointless because nothing has changed in them.
During their spree, the duo's crimes are reported by the press, and become a point of fascination for the entire country, with some people actually supporting them, and others afraid of them. When Manu enters a roadside tire shop to get some coffee, she is shot by the shop owner, who is then shot by Nadine outside. Nadine takes Manu's body to a forest and burns it, before driving to a beach. With tears in her eyes, Nadine puts the gun to her head, intending to commit suicide, but gets arrested by the police before she can do so.
